I have been running off and on for around 10 years. The first five I never got blisters, but the last 5 have I ever! I have tried every sock on the market, yes, Wright, 1000mile, anatomically correct ones, vaseline, 2nd skin, plasters, etc I even have a neat toe silicon cap - but nothing works!!! Yes, my shoes are okay and big enough - I have been to every store, and foot health depts here in UK and Canada - and try every remedy. I will try this Compeed andBody Glide as I cannot walk after a longer run. No I do not pop blisters because of infection, but when I used to it sure helped the pressure!