I have had kayano from the 14's.
Love them, never had heel blisters in any of them. Worth every penny to me. Just having orthotics made though so prob will have to change once they are ready to something more neutral although I have had off the shelf orthotics in kayanos for the past 2 years.
Absolutely love the Kayano - 3 years and still going strong although I get the feeling if I'd have bought the 21*0 from the other comments on here I may well be saying the same thing....
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