Craigyb
I regularly run to and from work, and my pack of choice is an Inov8 RacePro 22 (one size up from Kleesrosegarden). I think that they probably make the best running backpacks out there, but that they are definitely not the cheapest!
I also own an Osprey Talon 11 (bought when I temporarily lost my Inov8), and that is also pretty good. It's great in terms of the pack itself, and how much it carries, and how stable it is on your back, but it loses out to the Inov8 on things like the pockets on the belt, and how effective the compression system is when the pack is not full...