I think "safe" is the wrong word. Let's say I'd feel happier entering a big-name event abroad than the local running club one. (I am only talking about races abroad, not in the UK)
1. I want to visit countries where the primary language isn't English. There's a bigger chance of an official translation being on the website of a big event, some instructions being in English. Means less chances for me to make stupid mistakes with my dictionary and entering the wrong race, turning up at the wrong place, thinking something is provided on course and finding that it isn't.
2. I'd feel happier that the event would go ahead. Not saying that the big races never get cancelled (just look at the NY Marathon this year) but personally I wouldn't travel thousands of miles for a small race. Find a race to run if I'd already planned a trip? Fine. But I wouldn't base a holiday around a small indie race.
3. Compensation in case it did get cancelled. NY marathon runners got guaranteed entry into next year's event ... not sure that a small club could afford to do that in similar circumstances.
4. Overall experience. Road closures, well organised water stations, the race bling. I'm not going to travel to a different country specifically to run the equivalent of my running club's annual 20 miler, which is great but pretty informal, but I would to run a big name event.
None of this matters in the UK, because I don't have language-barrier, I can muddle along even if gel/water isn't provided on course, and at most I've lost the cost of a night's B&B if a race is unexpectedly cancelled.
Edited: 04/02/2013 at 15:26