AS already stated it depends if it is for general fitness or a specific distance event.
If you are say, running a 10k, then you will need to do that distance at least once a week in one go with shorter distance's at least 3 times a week to build speed.
If you just want to keep fit and have a target of say, 20k a week then do 4x 5k or 5x 4k or 2x 10k i could go on but i wont.
Doing the 10k once a week in one go will build stamina for that distance, if you only do shorter distances all week you will struggle to complete a 10k if needed.
Hope that makes sense.
Edited: 04/11/2008 at 11:42