trolling around these threads I realise that scotty is the very oracle of blisters, I wish I'd "met" you weeks ago!!
The only thing I can ad is that for a really painful blister, if you must run, is to use those hydrocolloid plasters, I find boots the biggest and best, careful putting them on though, if the sticky rucks up you cant reposition.
then tape across with the sugical tape, as I find the gel plasters ruck up on a run, and need replacing, which can be traumatic as they stick like glue even when rucked!!
The instructions say leave in place for 3-7 days, bit of a laugh really, at £1.30-odd each, I suppose if you stayed in bed for a week they might stay put!
Oh yes, and don't ever run with an unpricked blister on the weight bearing areas of your feet, they just get bigger!