Just read this thread with interest - I'm running in new trainers too, and having had a few problems with painful (but no blisters) arches, thought I'd made it but last night, after a six miler, I found i had not exactly blisters but a sore spot between my little toe and the next toe in, on both feet. Now I know what you're going to say - that the shoes are too tight, but I don't think they are - I can wiggle my toes up and down and even splay them quite happily (obviously the splaying technique is a personal idiosyncracy, but it's a test I use to see how tight shoes are in general!!). I don't really fancy taking tonight off as I'm planning to take tomorrow off to give my calf muscle a break before my long run on Saturday, but any suggestions to ease the sore points will be gratefully received.