Before I got my IBS meds I did once, in desperation, take more than the maximum dose of loperamide (immodium, generic) that it specified on the packet. I was struck down by a day of horrific headache, nausea, and generally feeling absolutely terrible - could do nothing but stay in bed I felt so sick. So learn from my mistake, and if the max safe dose of immod. doesn't work, talk to the GP - they have Prescrip. only stuff which can help.