If it's compartment syndrome caused by overpronation then supplements aren't really going to help. I suffer from this and the only way to cure properly is to fix the problem i.e. orthotics and physio. Stretching may help in the short term and icing will reduce inflamation, as will ibuprofen. Did you suddenly go out and run 36 miles in 5 days? If so, then it's no wonder it hurts! I would try resting for a while. I was forced to cut back recently, due to blisters, and it's made a huge improvement to my shins.