Trust your body and trust the plan. Some runs are always going to be harder than others. Make sure you are well hydrated and are eating properly to help regeneration. And don't be afraid to slow down when a run feels tough. Unless you have an ambitious time goal, training is more about spending time on your feet than hitting a certain pace. I used Higdons Novice 1 to train for Dublin last year (my first marathon). It got me to the start line as it says on the tin and I crossed the finish line with a smile. Dublin is great for a first marathon. There are a few smaller hills, most notably their version of "heartbreak hill" around mile 21, but the support is truly amazing. Make sure to soak up the atmosphere and have fun.