Paul,
22 mpw is low for knee problems to kick in, and suggests that either (a) the steady increase is too fast and you need to build up more gradually or (b) something is not right biomechanically, e.g. your shoes are not the right type for you, or are too old. Or it could be that although 22mpw is ok for you, you're trying to do too much quality work or just generally pushing too much in training.
There's certainly no harm in reducing your training to 3 sessions pw and say doing some cross-training (I'm currently rehabing an injury and doing something similar, although I'm gradually increasing the mileage and number of sessions running per week: cross-training can only do so much for you as a runner and certainly does very little for my sanity!) but I'd try and get to the bottom of what's causing the problem rather than simply adjusting the training and hoping it never recurs. A specialist running shop is a good place to start and if they can't resolve your problem with new footwear, a physio should probably be your next port of call.
The other difficulty is that, for a 3 session pw programme to work (i.e. deliver improved times, rather than simply get you to finish), the sessions have to be quite intensive (intervals, tempo runs, race-pace efforts, etc.) which in itself invites injury if your problem is biomechanical.