ive worn the 1140s and currently use the 1150s, both are good trainers and both offer width in the toe box. Im a big Asics fan and recently went for gait analysis after the heelbox in my 1140s went (lots of use), I tried virtually every trainer in the shop and came full circle to the 1150s - i love the shoe and run mostly road so Im bound to recommend them. I've never had blisters with Asics, but then again i have the skin of a rhino on my feet!
I had a similar problem when I first started running, both my calves would tighten like a vice and make it very uncomfortable to run.
I took myself down to my local running shop where i was given gait analysis, the new shoes i was fitted were perfect and my tight calves dissapeared overnight. It turned out the heel box on my old trainers had gone (you could actually hear the difference when i ran on the treadmill), which meant that my heel was lower than my forefoot and causing me the calf pain.
It may not be the same cause but gait analysis is great if you intend on running lots.