ACL rupture about 20 years ago when I played football. I was not a runner then.
Started running 8 years ago because I couldn't play sports with sharp stops and turns, like football and squash. Since then I have completed 7 marathons and an ultra-marathon amongst other shorter, faster races. I twisted it badly again 3 years ago in Toughguy because I didn't focus well enough when jumping into a ditch, so have stopped doing those too.
Bottom line is you can run successfully as long as you're aware of your shortcomings and are careful not to twist. I regularly do squats, lunges, balancing etc to keep the quads strong to help overall stability.