I have custom made orthotics that I have to wear in all my shoes. so I buy neutral trainers. If I don't use the orthotics I get pain in my knees. Before I had the orthotics prescribed for me I always wore a shoe to correct over pronation. If I wore neutral shoes back then, I got pain in my knees. I may be that one in a million oddities, I realise!!!
I've got the nimbus 15. I absolutely love them. My feet are a bit sensitive so I like the extra cushioning. I have to wear orthotics and so I need a neutral shoe like the nimbus. I haven't tried the W1080v3, though, so I can't make a comparison.
My best advice is to try them both on, preferably at the same time and somewhere that can look at your gait whilst you're trying them if possible.