I'm another large runner. I've found that running on trails and off road has helped me to shake some of the niggles.
I tend to have an older pair of shoes for training and a newer pair for races same make and model. When training pair dies I buy a new pair to race in. I've found that I get more miles out of my NB 890 than any other shoes I've used.
Once you start on off road shoes you will never be happy with one pair I have a pair of NB 101 awesome for most things except really muddy runs pretty minimal though. . Mizuno Wave Harriers like the NB but offer more protection. Had Kanadias and some asics but didn't get on with them. Also have more mile Cheviots for when it gets real muddy and x country or fell races.
For a one stop shop I would choose the Mizuno as the grip is good and they are ok on sections of road.