in the same position for the next three or four hours you will ultimately end up with very short hamstrings and calves. If you can make the time I would recommend doing some weekly flexibility stuff too - I am convinced that this lessens aches after running
running outside as it doesn't use the leg muscles in the same way. Although that's good for all-round toning, if you clock uploads of miles on the treadmill it'll build up your calves in the wrong places. – CraigBLet the treadmill dictate your pace I